The MESA College Prep program is a K-12 academic enrichment and college preparation STEM program offered in nine states. The program provides academic tutoring, hands-on engineering competitions, field trips, and STEM career pathways as well as teacher training. MESA is hosted by an established state office (district, community college, university, or non-profit) that oversees the day-to-day operations. Each approved host is expected to serve 50% or more students who are either 1) underrepresented in STEM careers (including girls of all backgrounds), or 2) attend economically disadvantaged schools.

The MESA University program offers retention support for undergraduate students in 4-year engineering programs. Students receive mentoring, academic tutoring, work study, professional and leadership development, career pathways education, a dedicated study space and a community environment to ensure successful degree completion.